Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on screening and treatment of tuberculosis infection in patients with inflammatory bowel disease
Gastroenterol Hepatol. 2021 Jan;44(1):51-66.
doi: 10.1016/j.gastrohep.2020.04.006.
Epub 2020 Aug 20.
[Article in
English,
Spanish]
Affiliations
- 1 Servicio de Aparato Digestivo, Hospital Universitario Central de Asturias e Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, España. Electronic address: sriestram7@gmail.com.
- 2 Servicio de Aparato Digestivo, Hospital Clínico San Carlos e Instituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, España.
- 3 Servicio de Aparato Digestivo, Hospital Universitari Mútua Terrassa, Barcelona, España; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas [CIBEREhd], Madrid, España.
- 4 Servicio de Aparato Digestivo, Complexo Hospitalario Universitario de Pontevedra e Instituto de Investigación Biomédica Galicia Sur (IBI), Pontevedra, España.
- 5 Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas [CIBEREhd], Madrid, España; Servicio de Aparato Digestivo, Hospital Universitari La Fe, Valencia, España.
- 6 Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas [CIBEREhd], Madrid, España; Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, España.
- 7 Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas [CIBEREhd], Madrid, España; Servicio de Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, España.
- 8 Servicio de Aparato Digestivo, Hospital Clínico Universitario de Santiago, Santiago de Compostela, España.
Abstract
There is evidence that following the recommendations on screening and treatment of tuberculosis infection does not completely prevent the onset of tuberculosis in patients with inflammatory bowel disease. This fact, and the increasing use of new biologics and immunomodulators, has led the Spanish Group Working on Crohn's Disease and Ulcerative Colitis to update their recommendations for the prevention of tuberculosis in patients with inflammatory bowel disease. Diagnostic methods for latent tuberculosis infection, different scenarios in which screening is to be performed, strategies to reduce the risk of tuberculosis once biological treatment is initiated and chemoprophylaxis guidelines for latent tuberculosis infection are reviewed, as well as the management of active tuberculosis during biological treatment. Finally, there is a summary of the current recommendations within the paper and in an algorithm.
Keywords:
Cribado; Enfermedad inflamatoria intestinal; Infección tuberculosa latente; Inflammatory bowel disease; Latent tuberculosis infection; Recomendaciones; Recommendations; Screening; Tuberculosis.
Copyright © 2020 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Adrenal Cortex Hormones / adverse effects
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Adrenal Cortex Hormones / therapeutic use
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Colitis, Ulcerative / drug therapy*
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Consensus*
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Crohn Disease / drug therapy*
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False Negative Reactions
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Humans
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use
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Incidence
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Interferon-gamma Release Tests
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Latent Tuberculosis / diagnosis*
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Latent Tuberculosis / etiology
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Latent Tuberculosis / prevention & control*
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Radiography, Thoracic
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Spain / epidemiology
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Tuberculin Test
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Tuberculosis / diagnosis
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Tuberculosis / epidemiology
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Tuberculosis / prevention & control
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Adrenal Cortex Hormones
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Immunosuppressive Agents
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Tumor Necrosis Factor-alpha