Regulation of peanut-specific CD8+ T cells from nonallergic individuals

Wong Yu; Xiaoying Zhou; Shu Chen Lyu; Mark M Davis; Kari C Nadeau

doi:10.1016/j.jaci.2020.07.032

Regulation of peanut-specific CD8⁺ T cells from nonallergic individuals

J Allergy Clin Immunol. 2021 Jan;147(1):385-387.e1. doi: 10.1016/j.jaci.2020.07.032. Epub 2020 Aug 21.

Authors

Wong Yu¹, Xiaoying Zhou¹, Shu Chen Lyu¹, Mark M Davis², Kari C Nadeau³

Affiliations

¹ Sean N. Parker Center for Allergy and Asthma Research at Stanford University School of Medicine, Stanford University School of Medicine, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, Calif.
² Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, Calif; Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, Calif; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, Calif.
³ Sean N. Parker Center for Allergy and Asthma Research at Stanford University School of Medicine, Stanford University School of Medicine, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, Calif. Electronic address: knadeau@stanford.edu.

Abstract

Peanut-specific CD8⁺ T cells in nonallergic individuals are not deleted, but have an expansion block that can be released by impairing regulatory T cell associated signaling pathways.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Plant
Arachis / immunology*
CD8-Positive T-Lymphocytes / immunology*
Female
Follow-Up Studies
HLA-A2 Antigen / immunology*
Humans
Male
Membrane Proteins
Plant Proteins

Substances

Antigens, Plant
Ara h 1 protein, Arachis hypogaea
HLA-A*02:01 antigen
HLA-A2 Antigen
Membrane Proteins
Plant Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding