CD226: An Emerging Role in Immunologic Diseases

Zhiyi Huang; Guangyin Qi; Joseph S Miller; Song Guo Zheng

doi:10.3389/fcell.2020.00564

CD226: An Emerging Role in Immunologic Diseases

Front Cell Dev Biol. 2020 Jul 24:8:564. doi: 10.3389/fcell.2020.00564. eCollection 2020.

Authors

Zhiyi Huang¹, Guangyin Qi¹, Joseph S Miller², Song Guo Zheng³

Affiliations

¹ Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
² Ohio University Heritage College of Osteopathic Medicine, Dublin, OH, United States.
³ Department of Internal Medicine, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, United States.

Abstract

CD226, a member of the immunoglobulin superfamily, is a functional protein initially expressed on natural killer and T cells. In recent years, the function of CD226 has been increasingly realized and researched. Accumulating evidence shows that CD226 is closely related to the occurrence of autoimmune diseases, infectious diseases, and tumors. Because of the CD226's increasing importance, the author herein discusses the structure, mechanism of action, and role of CD226 in various pathophysiological environments, allowing for further understanding of the function of CD226 and providing the basis for further research in related diseases.

Keywords: CD226; adhesion factor; autoimmune disease; immune; tumor.