SnapShot: β-Arrestin Functions

Seungkirl Ahn; Sudha K Shenoy; Louis M Luttrell; Robert J Lefkowitz

doi:10.1016/j.cell.2020.07.034

SnapShot: β-Arrestin Functions

Cell. 2020 Sep 3;182(5):1362-1362.e1. doi: 10.1016/j.cell.2020.07.034.

Authors

Seungkirl Ahn¹, Sudha K Shenoy², Louis M Luttrell³, Robert J Lefkowitz⁴

Affiliations

¹ Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
² Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
³ Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
⁴ Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

PMID: 32888497
DOI: 10.1016/j.cell.2020.07.034

Abstract

The arrestins are ubiquitously expressed adaptor proteins that orchestrate transmembrane signaling cascades triggered by the 7-transmembrane G protein-coupled receptors. While originally discovered as proteins that block receptor-G protein coupling, arrestins are now appreciated for their expanding repertoire of dynamic protein interactions and cellular functions.

MeSH terms

Arrestins / metabolism*
Cell Membrane / metabolism
Protein Interaction Maps / physiology
Receptors, G-Protein-Coupled / metabolism
Signal Transduction / physiology

Substances

Arrestins
Receptors, G-Protein-Coupled