Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation

Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118866. doi: 10.1016/j.bbamcr.2020.118866. Epub 2020 Sep 29.
No abstract available

Keywords: IL-23; IL-33; IL-36; Inflammation; MCPIP1; Psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Inflammation / genetics
  • Inflammation / pathology
  • Interleukin-23 / genetics*
  • Keratinocytes / metabolism
  • Keratinocytes / pathology
  • Psoriasis / genetics*
  • Psoriasis / pathology
  • Ribonucleases / genetics*
  • STAT3 Transcription Factor / genetics*
  • Signal Transduction / genetics
  • Skin / metabolism
  • Skin / pathology
  • Th17 Cells / metabolism
  • Transcription Factors / genetics*

Substances

  • Interleukin-23
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Transcription Factors
  • Ribonucleases
  • ZC3H12A protein, human