The CoViD-19 pandemic has pointed out the the need for an efficient, timely, ethically correct clinical research, in order to find rapid and reliable responses to health challenges. The guidelines published by the Agenzia Italiana del Farmaco during the pandemic have shown that some useful changes for simplifying and speeding-up clinical research in Italy are feasible, while maintaining high levels of quality. In this perspective, a reflection is a must: perhaps we are ready to detach ourselves from that image of a slow and bureaucratic country now widespread in Europe. Perhaps the pandemic has left us something good. Maybe we are really able of working much better, even in non-emergency conditions.