A Pituitary Society update to acromegaly management guidelines

Pituitary. 2021 Feb;24(1):1-13. doi: 10.1007/s11102-020-01091-7. Epub 2020 Oct 20.

Abstract

Guidelines and consensus statements ensure that physicians managing acromegaly patients have access to current information on evidence-based treatments to optimize outcomes. Given significant novel recent advances in understanding acromegaly natural history and individualized therapies, the Pituitary Society invited acromegaly experts to critically review the current literature in the context of Endocrine Society guidelines and Acromegaly Consensus Group statements. This update focuses on how recent key advances affect treatment decision-making and outcomes, and also highlights the likely role of recently FDA-approved therapies as well as novel combination therapies within the treatment armamentarium.

Keywords: Acromegaly; Growth hormone; Insulin-like growth factor I; Oral octreotide; Pegvisomant; Pituitary adenoma; Somatostatin receptor ligand.

Publication types

  • Review

MeSH terms

  • Acromegaly / blood*
  • Animals
  • Female
  • Human Growth Hormone / analogs & derivatives
  • Human Growth Hormone / blood
  • Human Growth Hormone / therapeutic use
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Octreotide / therapeutic use
  • Pituitary Neoplasms / blood
  • Receptors, Somatostatin / blood

Substances

  • Receptors, Somatostatin
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • pegvisomant
  • Octreotide