Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Jancy Johnson; Yu-Wen Wu; Chantelle Blyth; Gregor Lichtfuss; Hadi Goubran; Thierry Burnouf

doi:10.1016/j.tibtech.2020.10.004

Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Trends Biotechnol. 2021 Jun;39(6):598-612. doi: 10.1016/j.tibtech.2020.10.004. Epub 2020 Nov 4.

Authors

Jancy Johnson¹, Yu-Wen Wu², Chantelle Blyth³, Gregor Lichtfuss¹, Hadi Goubran⁴, Thierry Burnouf⁵

Affiliations

¹ Exopharm Ltd, Level 17, 31 Queen Street, Melbourne, VIC 3000, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia.
² Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
³ Exopharm Ltd, Level 17, 31 Queen Street, Melbourne, VIC 3000, Australia.
⁴ Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
⁵ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International PhD Program in Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: thburnouf@gmail.com.

PMID: 33160678
DOI: 10.1016/j.tibtech.2020.10.004

Abstract

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

Keywords: drug delivery; exosome; extracellular vesicle; platelet; regeneration.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Platelets*
Drug Delivery Systems
Extracellular Vesicles* / transplantation
Humans
Regenerative Medicine* / methods