The coordination between the animal's external environment and internal state requires constant modulation by chemicals known as neuromodulators. Neuromodulators, such as biogenic amines, neuropeptides and cytokines, promote organismal homeostasis. Over the past several decades, Caenorhabditiselegans has grown into a powerful model organism that allows the elucidation of the mechanisms of action of neuromodulators that are conserved across species. In this perspective, we highlight a collection of articles in this issue that describe how neuromodulators optimize C. elegans survival.
Keywords: C. elegans; neuromodulators; FMRFamide-like peptides; Octopamine; dopamine; homeostasis; insulin-like peptides; non-FLP; non-ILP neuropeptides; serotonin; survival; tyramine.