Chromosome segregation during female meiosis in C. elegans: A tale of pushing and pulling

J Cell Biol. 2020 Dec 7;219(12):e202011035. doi: 10.1083/jcb.202011035.

Abstract

The role of the kinetochore during meiotic chromosome segregation in C. elegans oocytes has been a matter of controversy. Danlasky et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.202005179) show that kinetochore proteins KNL-1 and KNL-3 are required for early stages of anaphase during female meiosis, suggesting a new kinetochore-based model of chromosome segregation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Anaphase
  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans Proteins* / genetics
  • Chromosome Segregation*
  • Female
  • Kinetochores
  • Meiosis
  • Microtubule-Associated Proteins / genetics
  • Oocytes

Substances

  • Caenorhabditis elegans Proteins
  • KNL-1 protein, C elegans
  • Microtubule-Associated Proteins