Cancer/Testis Antigens into mitochondria: a hub between spermatogenesis, tumorigenesis and mitochondrial physiology adaptation

Mitochondrion. 2021 Jan:56:73-81. doi: 10.1016/j.mito.2020.11.002. Epub 2020 Nov 19.

Abstract

Cancer/Testis Antigens (CTAs) genes are expressed only during spermatogenesis and tumorigenesis. Both processes share common specific metabolic adaptation related to energy supply, with a glucose to lactate gradient, leading to changes in mitochondrial physiology paralleling CTAs expression. In this review, we address the role of CTAs in mitochondria (mitoCTAs), by reviewing all published data, and assessing the putative localization of CTAs by screening for the presence of a mitochondrial targeting sequence (MTS). We evidenced that among the 276 CTAs, five were already shown to interfere with mitochondrial activities and 67 display a potential MTS.

Keywords: Cancer/Testis Antigen; Localization; Mitochondrion; Spermatogenesis; Tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Neoplasm / genetics*
  • Antigens, Neoplasm / metabolism
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Mitochondria / genetics
  • Mitochondria / metabolism*
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Spermatogenesis*
  • Testis / metabolism

Substances

  • Antigens, Neoplasm