We have uncovered a novel role for the nuclear receptor-binding SET domain protein 1 (NSD1) in human and murine erythroid differentiation. Mechanistically, we found that the histone methyltransferase activity of NSD1 is essential for chromatin binding, protein interactions and target gene activation of the erythroid transcriptional master regulator GATA1.
Keywords: GATA1; Histone methyltransferase; NSD1; erythroid differentiation; erythroleukemia.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.