Mining the Metabolome for New and Innovative Chagas Disease Treatments

Cristina Poveda; Maria Elena Bottazzi; Kathryn M Jones

doi:10.1016/j.tips.2020.11.007

Mining the Metabolome for New and Innovative Chagas Disease Treatments

Trends Pharmacol Sci. 2021 Jan;42(1):1-3. doi: 10.1016/j.tips.2020.11.007. Epub 2020 Nov 25.

Authors

Cristina Poveda¹, Maria Elena Bottazzi², Kathryn M Jones³

Affiliations

¹ Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
² Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA; Department of Biology, Baylor University, Waco, TX, USA.
³ Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. Electronic address: kathrynj@bcm.edu.

PMID: 33248705
DOI: 10.1016/j.tips.2020.11.007

Abstract

Identifying novel therapeutic targets for Chagas disease is a scientific priority. Recently, Hossain et al. used an innovative metabolomic approach to define disease tolerance mechanisms and identify therapeutic targets for Chagas disease. This is the first study translating metabolomic data to develop novel treatments for Chagas disease.

Keywords: Trypanosoma cruzi; metabolism; therapeutic targets.

Publication types

Comment

MeSH terms

Animals
Chagas Disease* / drug therapy
Humans
Metabolome
Microbiota*
Parasites*
Tropism
Trypanosoma cruzi*