Morphology-controllable cellulose/chitosan sponge for deep wound hemostasis with surfactant and pore-foaming agent

Abstract

Developing a facile and scalable synthetic route is important to explore the potential application of functional cellulose sponges. Here, a simple and efficient strategy to produce porous and hydrophilic cellulose sponges using surfactant and pore-foaming agent is demonstrated. The obtained cellulose sponges exhibit high water absorption capacity and rapid shape recoverability. The introduction of chitosan endows the chitosan/cellulose composite sponge with good mechanical properties. Inhibitory effects on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa are particularly proved. Besides, the result of the dynamic whole blood clotting time indicated that the chitosan/cellulose composite sponge has better coagulation ability than those of traditional gauze and gelatin sponge. Animal experiment further showed that rapid hemostasis within 105 s could be reached with the composite sponge. Good biocompatibility of the composite sponge is proved by the results of hemocompatibility and cytotoxicity, indicating an excellent candidate as a rapid hemostatic material.

Keywords: Cellulose sponge; Chitosan; Hemostasis; Pore-foaming agent; Surfactant.