PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

Nicola Curtin; Péter Bai

doi:10.3390/cancers12123494

PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

Cancers (Basel). 2020 Nov 24;12(12):3494. doi: 10.3390/cancers12123494.

Authors

Nicola Curtin¹, Péter Bai^{2

3

4}

Affiliations

¹ Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
² Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
³ MTA-DE Lendület Laboratory of Cellular Metabolism, 4032 Debrecen, Hungary.
⁴ Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Abstract

The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [...].

Publication types

Editorial