Review of management of laryngopharyngeal reflux disease

J-R Lechien; F Mouawad; F Bobin; E Bartaire; L Crevier-Buchman; S Saussez

doi:10.1016/j.anorl.2020.11.002

Review of management of laryngopharyngeal reflux disease

Eur Ann Otorhinolaryngol Head Neck Dis. 2021 Sep;138(4):257-267. doi: 10.1016/j.anorl.2020.11.002. Epub 2020 Nov 27.

Authors

J-R Lechien¹, F Mouawad², F Bobin³, E Bartaire⁴, L Crevier-Buchman⁵, S Saussez⁶

Affiliations

¹ Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium; Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Lille, Hôpital Claude Huriez, Lille, France. Electronic address: Jerome.Lechien@umons.ac.be.
² Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Lille, Hôpital Claude Huriez, Lille, France.
³ Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Department of Otolaryngology-Head and Neck Surgery, Polyclinique de Poitiers, Poitiers, France.
⁴ Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Department of Otorhinolaryngology and Head and Neck Surgery, GHICL Saint-Vincent-de-Paul Hospital, Faculté Libre de Médecine de Lille, Lille, France.
⁵ Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, Paris, France.
⁶ Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.

PMID: 33257265
DOI: 10.1016/j.anorl.2020.11.002

Abstract

This review was conducted according to the Patient/problem Intervention Comparison Outcome (PICO) Statements. Some studies reported that 10-30% of patients consulting in ENT come with presenting symptoms of laryngopharyngeal reflux (LPR), but the exact prevalence of LPR is still unknown. Management has not changed in 20 years despite a significant increase in the number of publications on epidemiology, clinical presentation, diagnosis and treatment. The development of hypopharyngeal-esophageal multichannel intraluminal impedance pH monitoring (HEMII-pH) and saliva pepsin detection now allow a new multidimensional diagnostic approach associating clinical scores to HEMII-pH and saliva pepsin detection. This new approach may enable personalized treatment according to LPR profile on HEMII-pH (acid, non-acid, mixed; upright, recumbent reflux episodes). Updated treatment of LPR could consist in a 3-month association of dietary measures, proton pump inhibitors, alginate and magaldrate, followed by treatment adaptation.

Keywords: Diagnosis; Laryngitis; Laryngopharyngeal; Reflux; Treatment.

Publication types

Review

MeSH terms

Esophageal pH Monitoring
Humans
Hypopharynx
Laryngopharyngeal Reflux* / diagnosis
Laryngopharyngeal Reflux* / drug therapy
Pepsin A
Saliva

Substances

Pepsin A