Single-Molecule Approved Surface Passivation

Andrés Manuel Vera; Philip Tinnefeld

doi:10.1016/j.str.2020.11.009

Single-Molecule Approved Surface Passivation

Structure. 2020 Dec 1;28(12):1269-1270. doi: 10.1016/j.str.2020.11.009.

Authors

Andrés Manuel Vera¹, Philip Tinnefeld²

Affiliations

¹ Department of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München, 80539 München, Germany. Electronic address: andres.vera-gomez@cup.lmu.de.
² Department of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München, 80539 München, Germany. Electronic address: philip.tinnefeld@cup.uni-muenchen.de.

PMID: 33264595
DOI: 10.1016/j.str.2020.11.009

Abstract

Single-molecule experiments reveal structure function relationships and biomolecular dynamics in physiologically relevant conditions. In this issue of Structure, Park et al. (2020) report an optimized surface passivation strategy with polyethylene glycol in a dense, contracted conformation. Assembly of a functional transcription pre-initiation complex is demonstrated.

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MeSH terms

Humans
Nanotechnology*
Polyethylene Glycols
RNA Polymerase II*

Substances

Polyethylene Glycols
RNA Polymerase II