Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Min Tian; Yingao Qi; Xiaoli Zhang; Zhihui Wu; Jiaming Chen; Fang Chen; Wutai Guan; Shihai Zhang

doi:10.3389/fcell.2020.604896

Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Front Cell Dev Biol. 2020 Nov 17:8:604896. doi: 10.3389/fcell.2020.604896. eCollection 2020.

Authors

Min Tian¹, Yingao Qi¹, Xiaoli Zhang¹, Zhihui Wu¹, Jiaming Chen¹, Fang Chen^{1

2

3}, Wutai Guan^{1

2

3}, Shihai Zhang^{1

2

3}

Affiliations

¹ Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
² College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
³ Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China.

Abstract

Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion.

Keywords: JAK2; Stat5; mammary gland development; milk production; signaling molecules.

Publication types

Review