Plugging a Leak: How Phagosomes "Stretch" to Accommodate Pathogen Growth

Chinaemerem U Onyishi; Guillaume E Desanti; Robin C May

doi:10.1016/j.chom.2020.11.005

Plugging a Leak: How Phagosomes "Stretch" to Accommodate Pathogen Growth

Cell Host Microbe. 2020 Dec 9;28(6):774-775. doi: 10.1016/j.chom.2020.11.005.

Authors

Chinaemerem U Onyishi¹, Guillaume E Desanti¹, Robin C May²

Affiliations

¹ Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
² Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: r.c.may@bham.ac.uk.

PMID: 33301715
DOI: 10.1016/j.chom.2020.11.005

Abstract

Phagocytes engulf pathogens into a membrane bound compartment called a phagosome, but what happens when engulfed pathogens start growing? In this issue of Cell Host & Microbe,Westman et al. (2020) show that lysosomes fuse with phagosomes to maintain phagosomal membrane integrity as the fungal pathogen Candida albicans expands.

Publication types

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MeSH terms

Candida albicans
Humans
Lysosomes
Mycoses*
Phagocytes
Phagosomes*