Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer

Kathleen M McAndrews; Yang Chen; Raghu Kalluri

doi:10.1016/j.ccell.2020.11.003

Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer

Cancer Cell. 2020 Dec 14;38(6):774-775. doi: 10.1016/j.ccell.2020.11.003.

Authors

Kathleen M McAndrews¹, Yang Chen¹, Raghu Kalluri²

Affiliations

¹ Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address: rkalluri@mdanderson.org.

PMID: 33321084
DOI: 10.1016/j.ccell.2020.11.003

Abstract

Cells within the tumor microenvironment can influence tumor progression; however, genetic alterations in stromal cell populations remain largely unexplored. In this issue, Zhou et al. combine multiomics single-cell sequencing and identify prevalent genetic alterations in colorectal cancer stromal cell populations.

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MeSH terms

Colorectal Neoplasms*
Humans
Stromal Cells*
Tumor Microenvironment