Capture and Kill: Selective Eradication of Target Bacteria by a Flexible Bacteria-Imprinted Chip

ACS Biomater Sci Eng. 2021 Jan 11;7(1):90-95. doi: 10.1021/acsbiomaterials.0c01568. Epub 2020 Dec 18.

Abstract

This paper reports an antibacterial chip that can selectively capture bacteria and kill them using low-voltage DC electricity. We prepared a bacteria-imprinted, flexible PDMS chip that can separate target bacteria from suspensions with high selectivity. The chip contained integrated electrodes that can kill the captured bacteria within 10 min by applying a low DC voltage. The used chip could be easily regenerated by solution immersion. Meanwhile, the PDMS chip showed good biocompatibility and inhibited adhesion of human blood cells. Our work points to a new strategy to address pathogenic bacterial contamination and infection.

Keywords: antibacterial; biocompatible; biomedical device; cell imprinting; specific.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents*
  • Bacteria*
  • Humans

Substances

  • Anti-Bacterial Agents