Increased number of neuroimaging studies has revealed association between age-related cognitive decline and alterations in the architecture of brain networks, while trials consistently confirmed benefits following cognitive training in the elderly. As a consequence, the present study aimed to investigate the potential moderating role of topological properties in brain structural network on training benefits. Among 32 community-dwelling older adults, 18 were randomly assigned to the training group to receive 24 sessions of multi-domain cognitive training (MDCT) over 12 weeks, and 14 to the control group. At baseline and 12-month follow-up, diffusion tensor imaging was acquired to construct the brain structural network, and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Visual Reasoning Test (VRT) were performed to assess cognitive functions. Compared with controls, participants received MDCT achieved significant larger gain in terms of delayed memory with a trend of better global cognitive function. In addition, Sigma coefficient of small-worldness were reduced in the MDCT group relative to the control group. Correlation between changes in Sigma and in delayed memory index were found among controls, however, not among older adults received MDCT. Our results demonstrated the modulating effects of cognitive training on the small-world architecture of brain structural network. And the present study suggested a trade-off mechanism underlying the benefits of cognitive training among aged people, where brain sacrificed its cost-effectiveness of network wiring for better cognitive functions.
Keywords: Cognitive training; Diffusion tensor imaging; Graph theory; Normal aging.
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