Methicillin-resistant Staphylococcus aureus (MRSA) panniculitis in a patient undergoing stem cell mobilisation

BMJ Case Rep. 2021 Feb 9;14(2):e236382. doi: 10.1136/bcr-2020-236382.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) can cause a wide range of skin infections, however MRSA panniculitis without bacteremia is a rare manifestation. Here, we report a woman in her 20s with relapsed Hodgkin lymphoma undergoing stem cell mobilisation who presented with bilateral subcutaneous nodules over her shins. Ultrasound scan of one nodule showed non-specific inflammatory changes. Punch biopsy of a nodule showed lobular panniculitis with Gram-positive cocci. Blood cultures were negative but a culture from the biopsy grew MRSA. She was started on doxycycline with improvement in her symptoms. This case serves as a reminder to consider infections as a cause of panniculitis in immunocompromised patients.

Keywords: dermatology; haematology (incl blood transfusion); pathology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Biopsy
  • Doxycycline / therapeutic use
  • Female
  • Hematopoietic Stem Cell Mobilization*
  • Hodgkin Disease / therapy
  • Humans
  • Immunocompromised Host
  • Methicillin-Resistant Staphylococcus aureus
  • Panniculitis / drug therapy
  • Panniculitis / microbiology*
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology*

Substances

  • Anti-Bacterial Agents
  • Doxycycline