Evaluation of long-term consumption of omeprazole disadvantages: a network analysis

Abdolrahim Nikzamir; Mostafa Rezaei-Tavirani; Mohhamadreza Razzaghi; Sina Rezaei Tavirani; Maryam Hamzeloo-Moghadam; Somayeh Esmaeili; Behzad Hatami; Alireza Ahmadzadeh

Evaluation of long-term consumption of omeprazole disadvantages: a network analysis

Gastroenterol Hepatol Bed Bench. 2020 Winter;13(Suppl1):S98-S105.

Authors

Abdolrahim Nikzamir¹, Mostafa Rezaei-Tavirani², Mohhamadreza Razzaghi³, Sina Rezaei Tavirani⁴, Maryam Hamzeloo-Moghadam⁵, Somayeh Esmaeili⁵, Behzad Hatami⁴, Alireza Ahmadzadeh²

Affiliations

¹ Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 33585010
PMCID: PMC7881401

Abstract

Aim: Evaluation of deregulated genes after long-term consuming of omeprazole via network analysis.

Background: Proton pump inhibitors (PPIs) are used to inhibit gastric high rate of acid secretion in patients. Omeprazole as a PPI is a common drug in this regard. Evaluation of long-term consumption of omeprazole is studied in the present study via its effects on the gene expression of "human coronary artery endothelial cells".

Methods: Net effect of the presence of omeprazole on gene expression profiles of "human coronary artery endothelial cells" was evaluated through data from gene expression omnibus (GEO). Results of protein-protein interaction (PPI) network analysis were assessed via biological process examination to find the critical deregulated genes after long-term consumption of omeprazole.

Results: "Negative regulation of muscle cell apoptotic process", "negative regulation of DNA binding", "telencephalon cell migration", "forebrain cell migration" "response to cadmium ion", "cell-cell recognition", "positive regulation of protein targeting to mitochondrion", and "central nervous system neuron development" were the clusters of biological processes that were associated to the long -term presence of omeprazole. The final critical deregulated genes were JAK2, PTK2, and NRG1.

Conclusion: It can be concluded that cell cycle, proliferation, and apoptosis and several essential biological processes are affected and nervous system is a possible target related to the long-term consumption of omeprazole.

Keywords: Gene expression; Long term consumption; Omeprazole.