Blue light opens the ORAI1 LOC(K)

Sonal Srikanth; Yousang Gwack

doi:10.1016/j.ceca.2021.102371

Blue light opens the ORAI1 LOC(K)

Cell Calcium. 2021 May:95:102371. doi: 10.1016/j.ceca.2021.102371. Epub 2021 Feb 18.

Authors

Sonal Srikanth¹, Yousang Gwack²

Affiliations

¹ Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address: ssrikanth@mednet.ucla.edu.
² Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address: ygwack@mednet.ucla.edu.

PMID: 33626404
DOI: 10.1016/j.ceca.2021.102371

Abstract

The current optogenetic tools to elevate cytoplasmic Ca²⁺ concentrations either do not have high ion selectivity or activate undesirable signaling pathways. He et al. (2021) generated a light-operated Ca²⁺ channel by integrating a photosensitive module directly into ORAI1 channels to selectively raise cytoplasmic Ca²⁺ levels.

Keywords: Light-operated Ca(2+) channel; Orai1; STIM1.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cytosol
HEK293 Cells
Humans
ORAI1 Protein
Stromal Interaction Molecule 1*

Substances

ORAI1 Protein
ORAI1 protein, human
Stromal Interaction Molecule 1

Grants and funding

R01 AI146352/AI/NIAID NIH HHS/United States