Acute Flare of Adult-Onset Autoimmune Enteropathy Associated With Cyclophosphamide

Jasmine Liu; Ziad Hindi; Tariq Aziz; Siwar Albashir

doi:10.14309/crj.0000000000000541

Acute Flare of Adult-Onset Autoimmune Enteropathy Associated With Cyclophosphamide

ACG Case Rep J. 2021 Feb 22;8(2):e00541. doi: 10.14309/crj.0000000000000541. eCollection 2021 Feb.

Authors

Jasmine Liu¹, Ziad Hindi², Tariq Aziz³, Siwar Albashir⁴

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
² Department of Medicine, Schulich School of Medicine and Dentistry, London, Ontario.
³ Division of Anatomical Pathology, McMaster University, Hamilton, Ontario, Canada.
⁴ Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.

Abstract

This is a case of adult-onset autoimmune enteropathy (AIE) in a 46-year-old man with multiple autoimmune conditions who presented with worsening disease process after receiving cyclophosphamide. We describe the investigations and management of this patient over a 6-year timeline. The diagnosis and management of AIE is challenging given the heterogeneity in clinicopathologic findings and a small number of adult case reports. We describe the current diagnostic criteria, review the literature on treatment options and outcomes, and discuss the evidence for cyclophosphamide in the treatment of AIE. Adult-onset AIE should be considered in the differential diagnosis of refractory diarrhea and weight loss.

Publication types

Case Reports