EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

Hypertension. 2021 Apr;77(4):1399-1411. doi: 10.1161/HYPERTENSIONAHA.120.16518. Epub 2021 Mar 1.

Abstract

[Figure: see text].

Keywords: PPAR gamma; blood pressure; prostaglandin E2; sodium chloride; vasodilation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Hypertension* / metabolism
  • Hypertension* / physiopathology
  • Kidney / blood supply
  • Mice
  • Muscle, Smooth, Vascular* / metabolism
  • Muscle, Smooth, Vascular* / physiopathology
  • Oxidative Stress
  • PPAR gamma / metabolism*
  • Receptors, Prostaglandin E, EP3 Subtype / metabolism*
  • Signal Transduction
  • Sodium Chloride / metabolism*
  • Vascular Resistance / physiology*
  • Vasodilation / immunology*
  • Vasodilation / physiology

Substances

  • PPAR gamma
  • Receptors, Prostaglandin E, EP3 Subtype
  • Sodium Chloride