Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Qingjin Cai; Wanshan Liao; Fangchao Xue; Xiaochen Wang; Weiming Zhou; Yanzhao Li; Wen Zeng

doi:10.1016/j.bioactmat.2020.12.021

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Bioact Mater. 2021 Feb 6;6(8):2557-2568. doi: 10.1016/j.bioactmat.2020.12.021. eCollection 2021 Aug.

Authors

Qingjin Cai¹, Wanshan Liao¹, Fangchao Xue¹, Xiaochen Wang¹, Weiming Zhou¹, Yanzhao Li², Wen Zeng^{1

2

3}

Affiliations

¹ Department of Cell Biology, Third Military Medical University, Chongqing, 400038, China.
² State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing, China.
³ Departments of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China.

Abstract

Tissue-engineered vascular grafts (TEVGs) have enormous potential for vascular replacement therapy. However, thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs (<6 mm) after transplantation. Endothelialization of TEVGs is a key point to prevent thrombosis. Here, we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts. Meanwhile, endothelial heterogeneity is also discussed. Based on it, we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.

Keywords: Tissue-engineered vascular grafts; endothelial heterogeneity; scaffold materials; seed cells; vascular endothelialization.

Publication types

Review