Induced pluripotent stem cell (iPSC) line (ZZUNEUi009-A) from a healthy female individual

Mengduan Liu; Xiaowei Li; Wanrong Fu; Mengyu Wang; Yangyang Liu; Lu Wang; Liang Hu; Xiaoyan Zhao; Jianzeng Dong

doi:10.1016/j.scr.2021.102275

Induced pluripotent stem cell (iPSC) line (ZZUNEUi009-A) from a healthy female individual

Stem Cell Res. 2021 May:53:102275. doi: 10.1016/j.scr.2021.102275. Epub 2021 Mar 3.

Authors

Mengduan Liu¹, Xiaowei Li¹, Wanrong Fu¹, Mengyu Wang¹, Yangyang Liu¹, Lu Wang¹, Liang Hu¹, Xiaoyan Zhao¹, Jianzeng Dong²

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, China.
² Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, China. Electronic address: jzdong@zzu.edu.cn.

PMID: 33730648
DOI: 10.1016/j.scr.2021.102275

Abstract

Induced pluripotent stem cells (iPSCs) can be used to generate different types of somatic cells in vitro and are a useful tool for investigating drug and disease mechanisms. Here, we generated human induced pluripotent stem cell (iPSC) line ZZUNEUi009-A from an apparently healthy 28-year-old female by reprogramming peripheral blood mononuclear cells with non-integrating vector. The generated iPSCs was pluripotent, maintained a stable karyotype, and could generate the three layers (ectoderm, mesoderm, and endoderm) in vitro.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cell Differentiation
Cellular Reprogramming
Endoderm
Female
Humans
Induced Pluripotent Stem Cells*
Karyotype
Leukocytes, Mononuclear
Mesoderm