Dual-Functional MN-08 Attenuated Pulmonary Arterial Hypertension Through Vasodilation and Inhibition of Pulmonary Arterial Remodeling

Hypertension. 2021 May 5;77(5):1787-1798. doi: 10.1161/HYPERTENSIONAHA.120.15994. Epub 2021 Mar 29.

Abstract

[Figure: see text].

Keywords: NMDA receptor; nitric oxide; pulmonary arterial hypertension; pulmonary vascular remodeling; vasodilation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Muscle, Smooth, Vascular / drug effects*
  • Myocytes, Smooth Muscle / drug effects*
  • Nitric Oxide Donors / pharmacology*
  • Nitric Oxide Donors / therapeutic use
  • Pulmonary Arterial Hypertension / drug therapy*
  • Rats
  • Vascular Remodeling / drug effects*
  • Vasodilation / drug effects*

Substances

  • Nitric Oxide Donors