Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report

Monira Abdullah Alnasser; Nour Marwan AlKhawajah; Nada Ghazi AlQadri; Asem Mustafa Shadid; Fahad M Alsaif

doi:10.1159/000512822

Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report

Case Rep Oncol. 2021 Mar 2;14(1):256-261. doi: 10.1159/000512822. eCollection 2021 Jan-Apr.

Authors

Monira Abdullah Alnasser¹, Nour Marwan AlKhawajah², Nada Ghazi AlQadri³, Asem Mustafa Shadid¹, Fahad M Alsaif²

Affiliations

¹ Department of Dermatology, King Fahad Medical City, Riyadh, Saudi Arabia.
² Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
³ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Abstract

Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype.

Keywords: CD4/CD8 double-negative mycosis fungoides; Cutaneous T-cell lymphomas; Erythrodermic mycosis fungoides; Mycosis fungoides.

Publication types

Case Reports