Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56dimCD16- NK cells

Xueling Jin; Liyuan Cui; Weijie Zhao; Xinyi Li; Lu Liu; Yanhong Li; Qiang Fu; Dajin Li; Min Yu; Meirong Du

doi:10.1038/s41423-021-00675-y

Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56^dimCD16^- NK cells

Cell Mol Immunol. 2021 Jun;18(6):1596-1598. doi: 10.1038/s41423-021-00675-y. Epub 2021 Mar 30.

Authors

Xueling Jin^#^{1

2}, Liyuan Cui^#^{1

2}, Weijie Zhao^{1

2}, Xinyi Li^{1

2}, Lu Liu^{1

2}, Yanhong Li^{1

2}, Qiang Fu^{1

2

3}, Dajin Li^{1

2}, Min Yu^{1

2}, Meirong Du^{4

5

6

7}

Affiliations

¹ NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China.
² Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
³ Department of Immunology, Binzhou Medical College, Yantai, China.
⁴ NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China. dmrlq1973@sina.cn.
⁵ Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China. dmrlq1973@sina.cn.
⁶ Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. dmrlq1973@sina.cn.
⁷ State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, SAR, China. dmrlq1973@sina.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CD56 Antigen / metabolism*
Cyclic AMP / metabolism*
Decidua / cytology*
Female
Forkhead Box Protein O1 / metabolism
Homeobox A10 Proteins / metabolism
Humans
Killer Cells, Natural / cytology*
Models, Biological
Phenotype
Pregnancy
Receptors, IgG / metabolism*
Stromal Cells / metabolism

Substances

CD56 Antigen
FOXO1 protein, human
Forkhead Box Protein O1
Homeobox A10 Proteins
Receptors, IgG
HOXA10 protein, human
Cyclic AMP

Grants and funding

31970859, 81630036, 91542116/National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)