Small Incision Lenticule Extraction (SMILE): Myths and Realities

Semin Ophthalmol. 2021 May 19;36(4):140-148. doi: 10.1080/08820538.2021.1887897. Epub 2021 Apr 6.

Abstract

The emergence of SMILE in the last decade has provided an alternative to LASIK for patients considering cornea laser refractive surgery. SMILE offers a novel approach using the femtosecond laser to create an intrastromal lenticule that can be removed through a small three to four millimeter incision.The purpose of this study is to review the recent literature on popular SMILE claims - reduced iatrogenic dry eye, better recovery of corneal sensation, and a biomechanically stronger cornea - summarize the published outcomes, and determine which claims are myths versus realities.SMILE is still in its infancy as a refractive technique in the US after recent USFDA approval for its treatment of myopia astigmatism in October 2018. Future randomized controlled studies are needed to compare its outcomes to LASIK, which has well-documented good visual outcomes, rapid postoperative recovery, and good safety profile.

Keywords: Corneal biomechanics; Corneal sensitivity; Dry eye; LASIK; SMILE.

Publication types

  • Review

MeSH terms

  • Astigmatism* / surgery
  • Cornea
  • Humans
  • Keratomileusis, Laser In Situ*
  • Myopia* / surgery
  • Prospective Studies