Disseminated Cryptosporidium infection in an infant with CD40L deficiency

Fleur Dupuy; Stéphane Valot; Frédéric Dalle; Arthur Sterin; Coralie L'Ollivier

doi:10.1016/j.idcr.2021.e01115

Disseminated Cryptosporidium infection in an infant with CD40L deficiency

IDCases. 2021 Apr 7:24:e01115. doi: 10.1016/j.idcr.2021.e01115. eCollection 2021.

Authors

Fleur Dupuy¹, Stéphane Valot², Frédéric Dalle², Arthur Sterin³, Coralie L'Ollivier^{1

4}

Affiliations

¹ IHU Méditerranée Infection, Marseille, France.
² Laboratoire de Parasitologie-Mycologie, CHU de Dijon, France.
³ Service d'hématologie pédiatrique, AP-HM La Timone, Marseille, France.
⁴ Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.

Abstract

The protozoan Cryptosporidium affects the digestive tract of humans and animals. Cryptosporidiosis leads to diarrhoea mimicking a cholera-like course with dehydration and may even result in death in immunodeficient patients, as patients with hyper-IgM syndrome. We describe a rare case of disseminated Cryptosporidium infection in a seven- year-old boy with CD40 L deficiency. During the pre-graft phase, the patient presented an intestinal cryptosporidiosis which became complicated few days later during the aplasia period with a cholangitis and pulmonary cryptosporidiosis. Cryptosporidium hominis was identified. After treatment with nitazoxanide and azithromycine the patient was doing well.

Keywords: CD40L deficiency; Cryptosporidium; Disseminated.

Publication types

Case Reports