Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

Bingyang Zhang; Di Liu; Wenyue Ji; Kouharu Otsuki; Koji Higai; Feng Zhao; Wei Li; Kazuo Koike; Feng Qiu

doi:10.3389/fchem.2021.649287

Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

Front Chem. 2021 Mar 30:9:649287. doi: 10.3389/fchem.2021.649287. eCollection 2021.

Authors

Bingyang Zhang¹, Di Liu¹, Wenyue Ji¹, Kouharu Otsuki², Koji Higai², Feng Zhao³, Wei Li², Kazuo Koike², Feng Qiu¹

Affiliations

¹ School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
² Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.
³ School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

Abstract

Seven undescribed cembranoids, sacraoxides A-G (1, 3-8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC₅₀ values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

Keywords: Boswellia sacra; anti-inflammatory; cembranoids; olibanum; phytochemistry; structure elucidation.