Immunometabolic regulation of adipose tissue resident immune cells

Gustavo Gastão Davanzo; Gisele Castro; Pedro Manoel M Moraes-Vieira

doi:10.1016/j.coph.2021.03.004

Immunometabolic regulation of adipose tissue resident immune cells

Curr Opin Pharmacol. 2021 Jun:58:44-51. doi: 10.1016/j.coph.2021.03.004. Epub 2021 Apr 18.

Authors

Gustavo Gastão Davanzo¹, Gisele Castro², Pedro Manoel M Moraes-Vieira³

Affiliations

¹ Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, SP, Brazil.
² Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, SP, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil.
³ Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, SP, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, SP, Brazil. Electronic address: pmvieira@unicamp.br.

PMID: 33878567
DOI: 10.1016/j.coph.2021.03.004

Abstract

Adipose tissue (AT) performs immunoregulatory functions beyond fat storage. In addition to adipocytes, AT has a diverse spectrum of resident and infiltrating immune cells in health and disease. Immune cells contribute to the homeostatic function of AT by adapting their metabolism in accordance with the microenvironment. However, how the metabolic reprogramming of immune cells affects their inflammatory profile and the subsequent implication for adipocyte function is not completely elucidated. Here, we discuss the available data on metabolic regulatory processes implicated in the control of adipose tissue-resident immune cells and their crosstalk with adipocytes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adipocytes*
Adipose Tissue*
Homeostasis