Thymoma and thymic carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations

Teresa Stachowicz-Stencel; Anna Synakiewicz; Marianna Cornet; Andrea Ferrari; Marina Garassino; Jordi Remon Masip; Rod Julien; Calogero Virgone; Dominik T Schneider; Ines B Brecht; Tal Ben-Ami; Ewa Bien; Yves Reguerre; Jan Godzinski; Gianni Bisogno; Daniel Orbach; Sabine Sarnacki

doi:10.1002/pbc.29042

Thymoma and thymic carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations

Pediatr Blood Cancer. 2021 Jun:68 Suppl 4:e29042. doi: 10.1002/pbc.29042. Epub 2021 Apr 21.

Authors

Teresa Stachowicz-Stencel¹, Anna Synakiewicz¹, Marianna Cornet², Andrea Ferrari³, Marina Garassino⁴, Jordi Remon Masip⁵, Rod Julien⁶, Calogero Virgone⁷, Dominik T Schneider⁸, Ines B Brecht⁹, Tal Ben-Ami¹⁰, Ewa Bien¹, Yves Reguerre¹¹, Jan Godzinski^{12

13}, Gianni Bisogno¹⁴, Daniel Orbach¹⁵, Sabine Sarnacki²

Affiliations

¹ Department of Pediatrics, Hematology and Oncology, Medical University, Gdansk, Poland.
² Department of Pediatric Surgery, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France.
³ Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁴ Thoraco-Pulmonary Medical Oncology Unit, Medical Oncology and Hematology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁵ Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
⁶ Department of Pediatric Surgery, University of Caen Hospital, Caen, France.
⁷ Pediatric Surgery, Department of Women's and Children's Health, University of Padua, Padua, Italy.
⁸ Clinic of Pediatrics, Dortmund Municipal Hospital, Dortmund, Germany.
⁹ Pediatric Oncology and Hematology, Children's Hospital, Eberhard-Karls-Universitaet, Tuebingen, Germany.
¹⁰ Pediatric Hematology Unit, Kaplan Medical Center, Rehovot, Israel.
¹¹ Department of Pediatric Hematology and Oncology, Félix Guyon University Hospital, Réunion Island, Saint-Denis, France.
¹² Department of Pediatric Surgery, Marciniak Hospital, Wroclaw, Poland.
¹³ Department of Pediatric Traumatology and Emergency Medicine, Wroclaw Medical University, Wroclaw, Poland.
¹⁴ Hematology and Oncology Division, Department for Women's and Children's Health, Padua University, Padua, Italy.
¹⁵ SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie, PSL University, Paris, France.

PMID: 33881200
DOI: 10.1002/pbc.29042

Abstract

Thymic tumors are epithelial tumors arising from the anterior mediastinum and constitute 0.2-1.5% of all adult malignancies but are exceptional in pediatric population. Thymic epithelial tumors (TETs) encompass a variety of histologic subtypes associated with different clinical outcomes. Due to its rarity in children, TETs' management requires a multidisciplinary approach. However, prognosis remains still poor, especially among patients with thymic carcinoma. This study presents the internationally recognized recommendations for the diagnosis and treatment of thymic tumors in children and adolescents, established by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) group within the EU-funded project Paediatric Rare Tumours Network - European Registry (PARTNER).

Keywords: EXPeRT; PARTNER; adolescents; children; guidelines; thymic carcinoma; thymic epithelial tumors; thymoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child
Humans
Neoplasms, Glandular and Epithelial*
Prognosis
Thymoma* / diagnosis
Thymoma* / pathology
Thymoma* / therapy
Thymus Neoplasms* / diagnosis
Thymus Neoplasms* / pathology
Thymus Neoplasms* / therapy