NLRP6 in host defense and intestinal inflammation

K Venuprasad; Arianne L Theiss

doi:10.1016/j.celrep.2021.109043

NLRP6 in host defense and intestinal inflammation

Cell Rep. 2021 Apr 27;35(4):109043. doi: 10.1016/j.celrep.2021.109043.

Authors

K Venuprasad¹, Arianne L Theiss²

Affiliations

¹ Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: venuprasad.poojary@utsouthwestern.edu.
² Division of Gastroenterology and Hepatology, School of Medicine at the Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.

Abstract

NLRP6 is a member of the NLR (nucleotide-oligomerization domain-like receptor) family of proteins that recognize pathogen-derived factors and damage-associated molecular patterns in the cytosol. The function of NLRP6 has been attributed to the maintenance of epithelial integrity and host defense against microbial infections. Under some physiological conditions, NLRP6 forms a complex with ASC and caspase-1 or caspase-11 to form an inflammasome complex cleaving pro-interleukin-1β (IL-1β) and IL-18 into their biologically active forms. Here, we summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Inflammasomes / metabolism*
Inflammation / physiopathology*
Intestinal Mucosa / pathology*
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding