Association between IL-8 (-251T/A) and IL-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis

Farzad Rezaei; Hady Mohammadi; Mina Heydari; Masoud Sadeghi; Hamid Reza Mozaffari; Atefeh Khavid; Mostafa Godiny; Serge Brand; Kenneth M Dürsteler; Annette Beatrix Brühl; Dominik Cordier; Dena Sadeghi-Bahmani

doi:10.3390/medicina57050405

Association between IL-8 (-251T/A) and IL-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis

Medicina (Kaunas). 2021 Apr 22;57(5):405. doi: 10.3390/medicina57050405.

Authors

Farzad Rezaei¹, Hady Mohammadi², Mina Heydari³, Masoud Sadeghi⁴, Hamid Reza Mozaffari⁵, Atefeh Khavid⁶, Mostafa Godiny⁷, Serge Brand^{8

9

10

11

12

13}, Kenneth M Dürsteler^{14

15}, Annette Beatrix Brühl^{9

10}, Dominik Cordier¹⁶, Dena Sadeghi-Bahmani^{8

9

10

12

17}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
² Department of Oral and Maxillofacial Surgery, Health Services, Kurdistan University of Medical Sciences, Sanandaj 6617713446, Iran.
³ Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
⁴ Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran.
⁵ Department of Oral and Maxillofacial Medicine, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
⁶ Department of Oral and Maxillofacial Radiology, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
⁷ Department of Endodontics, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
⁸ Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, Iran.
⁹ Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002 Basel, Switzerland.
¹⁰ Department of Clinical Research, University of Basel, 4031 Basel, Switzerland.
¹¹ Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, 4052 Basel, Switzerland.
¹² Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
¹³ School of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran.
¹⁴ Psychiatric Clinics, Division of Substance Use Disorders, University of Basel, 4052 Basel, Switzerland.
¹⁵ Center for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8001 Zurich, Switzerland.
¹⁶ Department of Neurosurgery, University Hospital Basel, 4031 Basel, Switzerland.
¹⁷ Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35209, USA.

Abstract

Background and objective: Inflammation and cell-mediated immunity can have significant roles in different stages of carcinogenesis. The present meta-analysis aimed to evaluate the association between the polymorphisms of IL-8 (-251T/A) and IL-6 (-174G/C) and the risk of oral cancer (OC).

Methods: PubMed/MEDLINE, Web of Science, Cochrane Library, and Scopus databases were searched until December 18, 2020 without any restrictions. RevMan 5.3 software was used to calculate the results of forest plots (odds ratios (ORs) and 95% confidence intervals (CIs)); CMA 2.0 software was used to calculate funnel plots (Begg's and Egger's tests), and SPSS 22.0 was used for the meta-regression analysis. Moreover, trial sequential analysis was conducted to estimate the robustness of the results.

Results: Eleven articles including twelve studies were selected for the meta-analysis. The pooled ORs for the association between IL-8 (-251T/A) polymorphism and the risk of OC in the models of A vs. T, AA vs. TT, TA vs. TT, AA + TA vs. TT, and AA vs. TT + TA were 0.97 (p = 0.78), 0.86 (p = 0.55), 0.78 (p = 0.37), 0.83 (p = 0.45), and 1.10 (p = 0.34), respectively. The pooled ORs IL-6 (-174G/C) polymorphism and the risk of OC in the models of C vs. G, CC vs. GG, GC vs. GG, CC + GC vs. GG, and CC vs. GG + GC were 1.07 (p = 0.87), 1.17 (p = 0.82), 1.44 (p = 0.38), 1.28 (p = 0.61), and 0.96 (p = 0.93), respectively. There was no association between IL-8 (-251T/A) polymorphism and OC susceptibility, but the C allele and GC and CC genotypes of IL-6 (-174G/C) polymorphism were associated with the risk of OC based on subgroup analyses, that is to say, the source of control and the genotyping method might bias the pattern of association.

Conclusions: The meta-analysis confirmed that there was no association between the polymorphisms of IL-6 (-174G/C) and IL-8 (-251T/A) and the susceptibility of OC. However, the source of control and the genotyping method could unfavorably impact on the association between the polymorphisms of IL-6 (-174G/C) and the risk OC.

Keywords: cytokine; interleukin; meta-analysis; oral carcinoma; oral cavity cancer; polymorphism.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Genetic Predisposition to Disease*
Humans
Interleukin-6 / genetics
Interleukin-8 / genetics
Mouth Neoplasms* / genetics
Polymorphism, Genetic
Risk Factors

Substances

Interleukin-6
Interleukin-8