Periosteal Tissue Engineering: Current Developments and Perspectives

Yiting Lou; Huiming Wang; Guanchen Ye; Yongzheng Li; Chao Liu; Mengfei Yu; Binbin Ying

doi:10.1002/adhm.202100215

Periosteal Tissue Engineering: Current Developments and Perspectives

Adv Healthc Mater. 2021 Jun;10(12):e2100215. doi: 10.1002/adhm.202100215. Epub 2021 May 3.

Authors

Yiting Lou^{1

2}, Huiming Wang¹, Guanchen Ye¹, Yongzheng Li¹, Chao Liu¹, Mengfei Yu¹, Binbin Ying²

Affiliations

¹ The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 395 Yan'an road, Hangzhou, Zhejiang, 310003, China.
² Department of Stomatology, The Ningbo Hospital of Zhejiang University, and Ningbo First Hospital, 59 Liuting street, Ningbo, Zhejiang, 315000, China.

PMID: 33938636
DOI: 10.1002/adhm.202100215

Abstract

Periosteum, a highly vascularized bilayer connective tissue membrane plays an indispensable role in the repair and regeneration of bone defects. It is involved in blood supply and delivery of progenitor cells and bioactive molecules in the defect area. However, sources of natural periosteum are limited, therefore, there is a need to develop tissue-engineered periosteum (TEP) mimicking the composition, structure, and function of natural periosteum. This review explores TEP construction strategies from the following perspectives: i) different materials for constructing TEP scaffolds; ii) mechanical properties and surface topography in TEP; iii) cell-based strategies for TEP construction; and iv) TEP combined with growth factors. In addition, current challenges and future perspectives for development of TEP are discussed.

Keywords: bone repair; periosteum; regenerative medicine; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Regeneration
Osteogenesis
Periosteum*
Stem Cells
Tissue Engineering*
Tissue Scaffolds