A PERKy way to make mitochondrial cristae

Barbara Cannon; Jan Nedergaard

doi:10.1016/j.tem.2021.04.003

A PERKy way to make mitochondrial cristae

Trends Endocrinol Metab. 2021 Jul;32(7):417-419. doi: 10.1016/j.tem.2021.04.003. Epub 2021 May 3.

Authors

Barbara Cannon¹, Jan Nedergaard²

Affiliations

¹ Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. Electronic address: barbara.cannon@su.se.
² Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

PMID: 33952415
DOI: 10.1016/j.tem.2021.04.003

Abstract

PERK protein, that is canonically associated with the response to endoplasmic reticulum stress, may be acquiring a new role as a regulator of the growth of mitochondrial cristae. This role is pertinent not only to the recruitment of brown adipose tissue thermogenic capacity but probably also to directing cristae formation in highly metabolically active organs such as the heart.

Keywords: MICOS; brown adipose tissue; cristae; endoplasmic reticulum stress; mitochondria; norepinephrine.

MeSH terms

Humans
Mitochondria*
Mitochondrial Membranes* / metabolism
Mitochondrial Proteins / metabolism

Substances

Mitochondrial Proteins