Stem cell models help crack regional oncohistone codes driving childhood gliomas

Rachel H Klein; Paul S Knoepfler

doi:10.1016/j.stem.2021.04.013

Stem cell models help crack regional oncohistone codes driving childhood gliomas

Cell Stem Cell. 2021 May 6;28(5):785-787. doi: 10.1016/j.stem.2021.04.013.

Authors

Rachel H Klein¹, Paul S Knoepfler²

Affiliations

¹ Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA; Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA.
² Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA; Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA. Electronic address: knoepfler@ucdavis.edu.

PMID: 33961758
DOI: 10.1016/j.stem.2021.04.013

Abstract

In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Glioma* / genetics
Histones / genetics
Humans
Mutation / genetics
Neural Stem Cells*
Oncogenes

Substances

Histones

Grants and funding

R01 NS106878/NS/NINDS NIH HHS/United States