Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia

Guannan Du; Yunan Zhang; Shoushan Hu; Xueer Zhou; Yi Li

doi:10.1016/j.ncrna.2021.04.001

Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia

Noncoding RNA Res. 2021 Apr 15;6(2):80-85. doi: 10.1016/j.ncrna.2021.04.001. eCollection 2021 Jun.

Authors

Guannan Du¹, Yunan Zhang¹, Shoushan Hu¹, Xueer Zhou¹, Yi Li¹

Affiliation

¹ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, PR China.

Abstract

Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes secreted by tumor play an important role in fat loss. However, there is no related reviews summarizing how ncRNAs contribute to fat loss during CC. This review screens recent articles to summarize how ncRNAs are packaged, transported in exosomes, and play the role in fat loss. Not only does this review summarize the mechanisms, we also point out the research orientations in the future.

Keywords: Cancer cachexia; Exosomes; Fat loss; Non-coding RNAs.