MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA

Radiology. 1988 Mar;166(3):835-8. doi: 10.1148/radiology.166.3.3401296.

Abstract

The enhancement properties of gadolinium diethylenetriaminepentaacetic acid (DTPA) and gadolinium tetraazacyclododecanetetraacetic acid (DOTA) were compared using a rat glioma model. In vitro analysis included the calculation of T1 relaxivity and determination of characteristic curves. Enhancement of the intracerebral glioma was studied in 23 rats approximately 2 weeks after glioma implantation with Gd-DTPA in 12 rats and Gd-DOTA in 11 rats. Six rats were also studied 1 week after implantation. Gd-DTPA exhibited a slightly greater T1 relaxivity in vitro than Gd-DOTA. Enhancement of the glioma was also greater with Gd-DTPA than with Gd-DOTA (P less than .05).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Neoplasms / diagnosis*
  • Gadolinium DTPA
  • Gadolinium*
  • Glioma / diagnosis*
  • Heterocyclic Compounds*
  • Magnetic Resonance Imaging*
  • Male
  • Organometallic Compounds*
  • Pentetic Acid*
  • Rats
  • Rats, Inbred Strains

Substances

  • Heterocyclic Compounds
  • Organometallic Compounds
  • Pentetic Acid
  • gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
  • Gadolinium
  • Gadolinium DTPA