A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

Cell Signal. 2021 Sep:85:110073. doi: 10.1016/j.cellsig.2021.110073. Epub 2021 Jul 3.

Abstract

The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain protein family with multifunctional properties both in the cytoplasm and inside the nucleus. YB-1 is also involved in various cellular functions, including regulation of transcription, mRNA stability, and splicing. Recent studies have associated YB-1 with the regulation of the malignant phenotypes in several tumor types. In this review article, we provide an in-depth and expansive review of the literature pertaining to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer development, progression, metastasis, and drug resistance in various malignancies, with more weight on literature published in the last decade. The methodology included querying databases PubMed, Embase, and Google Scholar for Y box binding protein 1, YB-1, YBX1, and Y-box-1.

Keywords: Cancer; Cancer stem cells;immunotherapy; Chemoresistance; Triple negative breast cancer; YB-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Nucleus / metabolism
  • Drug Resistance, Neoplasm
  • Humans
  • Neoplasms* / drug therapy
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • RNA Stability
  • Y-Box-Binding Protein 1* / chemistry
  • Y-Box-Binding Protein 1* / genetics
  • Y-Box-Binding Protein 1* / metabolism

Substances

  • Y-Box-Binding Protein 1
  • YBX1 protein, human