Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age

Isabelle Grenier-Pleau; Sheela A Abraham

doi:10.1016/j.exphem.2021.08.004

Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age

Exp Hematol. 2021 Sep:101-102:7-15. doi: 10.1016/j.exphem.2021.08.004. Epub 2021 Aug 15.

Authors

Isabelle Grenier-Pleau¹, Sheela A Abraham²

Affiliations

¹ Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
² Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address: sa183@queensu.ca.

PMID: 34407444
DOI: 10.1016/j.exphem.2021.08.004

Abstract

Extracellular vesicles (EVs) are small lipid bilayer particles containing biologically important cargo and impart regulatory changes in target cells. Despite the importance of EVs in cellular communication, there remains a gap in our understanding of how EVs influence HSC fate and, in turn, how aging and longevity are affected. This review summarizes the current literature dealing with how age-altered intercellular communication mediated by EVs influences HSC biology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging
Animals
Cell Communication*
Extracellular Vesicles / metabolism*
Hematopoiesis
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism
Humans

Abstract

Publication types

MeSH terms

Grants and funding