Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019

James Regan; James P Flynn; Alexandra Rosenthal; Hannah Jordan; Yijia Li; Rida Chishti; Francoise Giguel; Heather Corry; Kendyll Coxen; Jesse Fajnzylber; Elizabeth Gillespie; Daniel R Kuritzkes; Nir Hacohen; Marcia B Goldberg; Michael R Filbin; Xu G Yu; Lindsey Baden; Ruy M Ribeiro; Alan S Perelson; Jessica M Conway; Jonathan Z Li; MGH COVID-19 Collection & Processing Teams

doi:10.1093/ofid/ofab153

Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019

Open Forum Infect Dis. 2021 Apr 17;8(8):ofab153. doi: 10.1093/ofid/ofab153. eCollection 2021 Aug.

Authors

James Regan¹, James P Flynn¹, Alexandra Rosenthal¹, Hannah Jordan¹, Yijia Li¹, Rida Chishti¹, Francoise Giguel², Heather Corry¹, Kendyll Coxen¹, Jesse Fajnzylber¹, Elizabeth Gillespie¹, Daniel R Kuritzkes¹, Nir Hacohen^{2

3}, Marcia B Goldberg^{2

3}, Michael R Filbin^{2

3}, Xu G Yu^{1

2

4}, Lindsey Baden¹, Ruy M Ribeiro⁵, Alan S Perelson^{5

6}, Jessica M Conway⁷, Jonathan Z Li¹; MGH COVID-19 Collection & Processing Teams

Collaborators

MGH COVID-19 Collection & Processing Teams:
Betelihem A Abayneh, Patrick Allen, Galit Alter, Diane Antille, Katrina Armstrong, Alejandro Balazs, Julia Bals, Max Barbash, Yannic Bartsch, Julie Boucau, Siobhan Boyce, Joan Braley, Karen Branch, Katherine Broderick, Julia Carney, Andrew Chan, Josh Chevalier, Fatema Chowdhury, George Daley, Susan Davidson, Michael Dougan, David Drew, Kevin Einkauf, Ashley Elliman, Jon Fallon, Liz Fedirko, Kelsey Finn, Keith Flaherty, Jeanne Flannery, Pamela Forde, Pilar Garcia-Broncano, Elise Gettings, David Golan, Amanda Griffin, Sheila Grimmel, Kathleen Grinke, Kathryn Hall, Ciputra Hartana, Meg Healy, Howard Heller, Deborah Henault, Grace Holland, Chenyang Jiang, Nikolaus Jilg, Paulina Kaplonek, Marshall Karpell, Chantal Kayitesi, Evan C Lam, Vlasta LaValle, Kristina Lefteri, Xiaodong Lian, Mathias Lichterfeld, Daniel Lingwood, Hang Liu, Jinqing Liu, Yiting Lu, Sarah Luthern, Natasha Ly, Jordan Marchewka, Britanni Martino, Roseann McNamara, Ashlin Michell, Ilan Millstrom, Noah Miranda, Christian Nambu, Susan Nelson, Marjorie Noone, Claire O'Callaghan, Christine Ommerborn, Mathew Osborn, Lois Chris Pacheco, Nicole Phan, Shiv Pillai, Falisha A Porto, Yelizaveta Rassadkina, Alexandra Reissis, Alex Rosenthal, Francis Ruzicka, Edward Ryan, Kyra Seiger, Kathleen Selleck, Libera Sessa, Arlene Sharpe, Christianne Sharr, Sally Shin, Nishant Singh, Sue Slaughenhaupt, Kimberly Smith Sheppard, Weiwei Sun, Xiaoming Sun, Elizabeth Suschana, Hannah Ticheli, Alicja Trocha-Piechocka, Vivine Wilson, Colline Wong, Daniel Worrall, Alex Zhu, Zachary Manickas Hill, Edward Demers, Kelly Judge, Bruce Walker, Peggy Lai, Jonathan Li, Musie S Ghebremichael

Affiliations

¹ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
³ Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
⁴ Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts, USA.
⁵ Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
⁶ New Mexico Consortium, Los Alamos, New Mexico, USA.
⁷ Department of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, USA.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

Keywords: COVID-19; SARS-CoV-2; remdesivir; viral kinetics; viral load.

Abstract

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