Not just a 'drain': venules sprout brain capillaries

Christina N Como; Hannah E Jones; Julie A Siegenthaler

doi:10.1016/j.tins.2021.08.004

Not just a 'drain': venules sprout brain capillaries

Trends Neurosci. 2021 Nov;44(11):849-851. doi: 10.1016/j.tins.2021.08.004. Epub 2021 Aug 24.

Authors

Christina N Como¹, Hannah E Jones², Julie A Siegenthaler³

Affiliations

¹ Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
² Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Cell Biology, Stem Cells, and Development Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Cell Biology, Stem Cells, and Development Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: julie.siegenthaler@cuanschutz.edu.

PMID: 34452754
DOI: 10.1016/j.tins.2021.08.004

Abstract

The cerebral cortex requires a dense, highly organized network of vasculature that ensures high-volume and continuous oxygen delivery to metabolically active neuronal circuits. In a recent paper, Coelho-Santos et al. used in vivo two-photon microscopy to reveal how this precise network is constructed during a short window of mouse postnatal development.

Keywords: brain angiogenesis; brain development; capillary; cerebrovasculature; neurovascular unit; pericyte.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Brain / blood supply
Capillaries*
Cerebral Cortex
Humans
Mice
Pericytes*
Venules

Abstract

Publication types

MeSH terms

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