Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor

Kaho Suzuki; Yousuke Takaoka; Minoru Ueda

doi:10.1039/d0cb00204f

Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor

RSC Chem Biol. 2021 Jan 5;2(2):499-502. doi: 10.1039/d0cb00204f. eCollection 2021 Apr 1.

Authors

Kaho Suzuki¹, Yousuke Takaoka¹, Minoru Ueda^{1

2}

Affiliations

¹ Graduate School of Science, Tohoku University 6-3, Aramaki-Aza-Aoba Aoba-ku Sendai 980-8578 Japan ytakaoka@tohoku.ac.jp.
² Graduate School of Life Science, Tohoku University 6-3, Aramaki-Aza-Aoba Aoba-ku Sendai 980-8578 Japan.

Abstract

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.