Mini-review: The suspected non-Alzheimer's disease pathophysiology

Neurosci Lett. 2021 Nov 1:764:136208. doi: 10.1016/j.neulet.2021.136208. Epub 2021 Aug 31.

Abstract

Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based concept that underlying etiology has not been completely understood. Refers to a group of individuals that are negative for amyloid biomarkers and positive for p-Tau and/or neurodegeneration. SNAP causes great research interest because it is not clear if they have a different biological basis from Alzheimer's disease (AD), or are in an early stage of AD itself. The pathological processes behind SNAP need to be clarified. This mini-review aims to summarize the main characteristics of SNAP, besides reporting challenges and promising biomarkers related to the concept.

Keywords: Alzheimer’s disease; Biomarkers; Neurodegeneration; Suspected non-Alzheimer’s disease pathophysiology; Tau.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Aging / pathology
  • Amyloid beta-Peptides / analysis
  • Amyloid beta-Peptides / metabolism
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Brain / pathology*
  • Cognitive Dysfunction / diagnosis*
  • Cognitive Dysfunction / pathology
  • Disease Progression
  • Humans
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / pathology
  • tau Proteins / analysis*
  • tau Proteins / metabolism

Substances

  • Amyloid beta-Peptides
  • Biomarkers
  • tau Proteins